Abstract
Background: Osseointegration is the biological foundation of implant success. Injectable Platelet-Rich Fibrin (i-PRF), a liquid form of platelet concentrate, is rich in growth factors including PDGF, TGF-β, VEGF, and IGF-1, and has been proposed as a biofunctionalization agent for implant surfaces to enhance the biological cascade during healing.
Objective: This case series aimed to evaluate the clinical outcomes following i-PRF biofunctionalization of dental implants at the time of placement to enhance osseointegration.
Case Descriptions: Multiple patients with partially edentulous ridges were treated with dental implants biofunctionalized with i-PRF. Clinical and radiographic assessments were performed at baseline and at defined follow-up intervals.
Outcomes: All treated implants achieved stable osseointegration. Implant stability quotients (ISQ) demonstrated favorable trends. Radiographic bone levels were maintained within acceptable thresholds.
Conclusion: i-PRF biofunctionalization may offer a promising adjunct strategy to enhance osseointegration in dental implant placement. Controlled clinical trials are warranted for further validation.